Yan, L., Levine, R.L., Sohal, R.S. (1997). “Oxidative damage during aging targets mitochondrial aconitase.”
This is a most thought-provoking article. You will find it a bit challenging to read, technically, just focus on the discussion and conclusion. It is the message that is very important and very unsettling.
Aconitase is a critical piece of the metabolic puzzle, as we’ll be finding out in the coming weeks. It is a key iron-sulfur [4Fe-4S] cluster protein that must have bioavailable copper to work properly.
For those who want to know more about this interesting “moonlighting” enzyme:
Have fun watching those houseflies walking and now you will know why!
A votre sante,
MORLEY M. ROBBINS
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