(Formerly #5)
The underlying pathogenic event in oxidative stress is cellular iron mismanagement and how is iron is managed inside our cells and bodies.
“The underlying pathogenic event in oxidative stress is cellular iron mismanagement.”
Thompson, K.I. et al (2001) “Iron & Neurodegenerative Disorders.” Brain Research Bulletin, 55: 155-164)
https://www.ncbi.nlm.nih.gov/pubmed/11470311
For those seeking the granular truth of how iron is managed inside our cells and inside our bodies:
- Role of Cp on iron regulation:
Roeser, H.P. et al. (1970).”The role of ceruloplasmin in iron metabolism.”
www.ncbi.nlm.nih.gov/pmc/articles/PMC322742/pdf/jcinvest00228-0276.pdf
(pay particular attention to Fig. 6. below)
- Role of Cp on iron regulation in copper deficient rats:
Evans, J. L., Abraham, P.A. (1973). “Anemia, Iron Storage and Ceruloplasmin in Copper Nutrition in the Growing Rat
jn.nutrition.org/content/103/2/196.full.pdf - Role of Cp on regulation of the iron hormone, hepcidin:
Kono, S. et al. (2010). “Biological effects of mutant ceruloplasmin on hepcidin-mediated internalization of ferroportin
sciencedirect.com/science/article/pii/S0925443910001481 - Role of Fe- and Cu-homeostatic mechanisms in Neuro-disorders:
Skjorringe, T. et al. (2012). “Impairment of interrelated iron- and copper homeostatic mechanisms in brain contributes to the pathogenesis of neurodegenerative disorders.”
journal.frontiersin.org/article/10.3389/fphar.2012.00169/full
A votre sante!
MORLEY M. ROBBINS
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