Magnesium deficiency causes Epigenetic Stress!

Posted on August 6, 2013 by Morley Robbins


In a recent FB thread, several MAG-pies were commenting on the notable rise of missing enzymes, esp. those that are key to methylation and sulphation (i.e. MTHFR and CBS)

It’s a timely and important topic… Here’s a summary of some of my Mg-oriented observations that are worth understanding as it relates to this cultural metabolic shift that is sweeping the nation…
Please note the following:
o “Stress!” causes an automatic depletion of 3 key nutrients: Zinc, Magnesium & B-Vitamins…
o The Perception of
“Stress!” (whether a tiger or a toxin) is ENLARGED by a Magnesium deficiency and it’s impact on the Hypothalamus — it is the Master of Perception in our body… Everything is perceived BIGGER & BADDER when Mg is low…
o Genes are circuit breakers — just like the one’s in your basement… They flip on/off. They are NOT in concrete. They are mutable and they are changeable, under the right conditions, and circumstances.
o The job of genes is to make proteins, which then get made into enzymes when vitamin(s) & mineral(s) gets added…
o Given my “Magnesium-myopia,” I have only researched the impact of Mg deficiency on the performance of genes, as follows:
   1) ALL 3 DNA Ligase enzymes (I, II, & III) are activated by Mg and address “nicks” (I), “single strand breaks” (II) &  “double strand breaks” (III)
   2) Riboflavin (B2) plays an ongoing role in the maintenance, repair and overall health of DNA –> B2 is activated by Mg
   3) The entire process of mitosis and DNA replication is regulated by Mg-activated enzymes
   4) Riboflavin (B2) is the backbone of RNA (Ribonucleic Acid)
   5) The energy needed to perform genetic tasks is provided by Mg-ATP…
   6) The Adenine (B4) is the back-bone of ATP. Adenine (B4) is activated by Mg. Also, there are 5 components to make ATP, 4 of them are Mg-dependent
   7) At the genetic level, Heat Stress Proteins (HSP 30, 60, 70, 90, etc.) surface when Mg deficiency reaches a critical threshold.
o When “Stress!” overwhelms the genes, they flip the epigenetic switch and don’t work effectively and stop making the right proteins => enzymes, apparently due to a lack of Zinc, Mg, & B-Vitamins, among other factors…


ALL THAT SAID, THE PROCESS “BACK” IS NOT SIMPLY “TAKE MO’ MAGGIE!”

I KNOW THAT, AND FIRMLY BELIEVE “IT TAKES A VILLAGE.” MY POINT IS THAT I DON’T THINK ENOUGH ATTENTION IS BEING GIVEN TO RESTORING Mg STATUS TO RESTORE THE => BODY >> ORGAN >> CELLULAR >>GENETIC “STRESS RESPONSE…”

Given the metabolic facts above, it’s seems central to the process of recovery.
Thoughts?…