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Iron Toxicity Post #21: We are ‘Dead Flies Walking’
Formally #24
Yan, L., Levine, R.L., Sohal, R.S. (1997). “Oxidative damage during aging targets mitochondrial aconitase.”
https://www.pnas.org/doi/pdf/10.1073/pnas.94.21.11168
This is a most thought-provoking article. You will find it a bit challenging to read, technically, just focus on the discussion and conclusion. It is the message that is very important and very unsettling.
Aconitase is a critical piece of the metabolic puzzle, as we’ll be finding out in the coming weeks. It is a key iron-sulfur [4Fe-4S] cluster protein that must have bioavailable copper to work properly.
For those who want to know more about this interesting “moonlighting” enzyme:
“Aconitase”
https://proteinswebteam.github.io/interpro-blog//potm/2007_5/Page2.htm
Have fun watching those houseflies walking and now you will know why!
A votre sante,
MORLEY M. ROBBINS
For Facebook discussion:
https://www.facebook.com/groups/MagnesiumAdvocacy/permalink/973984906002912/
