Iron Toxicity Post #54: A Tale of Two Cities
Posted on March 12, 2017 by Morley Robbins
When you or your practitioner suspect that you have any issues with your proper copper<>iron status, these are the many elements that are intimately involved in your copper<>iron metabolism and thus should be the basis of your quest for proper and complete answers. Note the dual nature of many of these elements:
- Magnesium RBC
- Ferrous (Fe II) iron
- Ferric (Fe III) iron
- Ferritin Heavy-chain form
- Ferritin Light-chain form
- Ferritin mitochondrial form which is for the health of brain, heart, liver, thymus, and gonads
- Cuprous (Cu I) copper
- Cupric (Cu II) copper
- Oxygen, found on hemoglobin, inside ferroxidase enzyme and inside ferritins
- Ceruloplasmin with ferroxidase (FOX) function
- Ceruloplasmin without ferroxidase function and only acute phase reactant response
- Anemia of Iron Deficiency (indicates an absolute deficiency of iron)
- Anemia of Chronic Inflammation (Indicates an absolute deficiency of bioavailable copper)
If you think just measuring your ferritin status, despite the fact that it exists in three states noted above. Then we have no clue what the blood test is really assessing. Which you would think is a clinically valid and metabolically responsible approach! I encourage you to keep reading.
What I want to stress with you in this post is that
anemia does not mean iron deficiency!
I know how outrageously heretical that statement is. But I also know unlike your practitioner that true and absolute iron deficiency is next to impossible on a planet that has iron comprising 36% of the Earth’s composition, thereby making it the #1 element on the planet.
What is critical to this dynamic is the understanding the slight-of-hand that is appearing with increasing frequency in the leading iron research studies.
Iron deficiency means lack of functional iron!
I have now seen it in three different research studies. The iron researchers stating this know that it is bioavailable copper that is key to making iron functional. They know this truth, and by now, I’m hoping you do, too!
I would sincerely ask you to do right now, is take 30 minutes out of your day, and read this vital research on a new discovery in the battle against neurodegeneration:
Yang, H., et al. (2013). “Mitochondrial ferritin in neurodegenerative diseases.”
Yes, this article has big words in it. But this article has some of the most important insights that I have read about iron in a long time which are:
- •Mitochondrial ferritin (FtMt) is a novel protein localized to the mitochondria.
- •FtMt is expressed in restricted tissues including the brain, heart, kidney, thymus and gonads.
- FtMt lacks iron regulatory elements and its expression is increased by oxidative stress. [That is a big deal!]
- FtMt is increased in the cerebral cortex of Alzheimer disease (AD) patients and in the substantia niagra (SN) of individuals with Parkinson’s disease (PD) and Restless Leg Syndrome (RLS).
- The presence of FtMt prevents cell death induced by oxidative stress and neurotoxic proteins.
The two most important sentences of this study, in my humble opinion, are:
“…FtMt, which also possesses ferroxidase activity.”
Which means this critical protein; ferroxidase (FOX) can’t do anything without bioavailable copper, aka ceruloplasmin (Cp = FOX).
“Mitochondrial Ferritin (FtMt) overexpression showed a neuroprotective effect against hydrogen peroxide (H2O2) induced oxidative stress and amyloid beta-induced neurotoxicity in neuroblastoma cells”
Bioavailable copper coming to the rescue of tissue being assaulted by iron-induced oxidative stress!
What this means is that a healthy body has a naturally occurring mechanism to metabolize neurotoxic iron that is only possible with mitochondrial ferritin that depends on ferroxidase function. This is only possible in a body that has optimal levels of bioavailable copper.
I wonder if your practitioner even knows, understands or agree with this?
Here is my take:
- How little does your doctor really know about iron toxicity?
- There is no such thing as iron metabolism as it is only copper<>iron metabolism.
- Bioavailable copper regulates iron status and lack of copper creates iron toxicity.
- You are not anemic from iron deficiency but lack of functional iron, which causes anemia of chronic inflammation.
- Iron supplements and iron infusions make this dynamic worst and may even develop neurodegeneration.
Here is my take:
- Please watch my “Theory of Everything” Video
- Please learn and understand your true mineral status via HTMA and blood testing.
- Please get a “Copernican (RCP) inspired” consult to learn how the stress mosaic of your life created the mineral dysregulation that you are now expressing.
- Please understand that mineral dysregulation created the “Ferrous Wheel” and the consequence creation of symptoms that are expressions from iron-induced oxidative stress.
- Please start with the Root Cause Protocol (RCP) – even before you have a consult so you can begin to initiate mineral balance that will then allow metabolic recovery and optimal function.
A votre sante!
Morley M Robbins
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