Introduction

The foundation of understanding the Root Cause Protocol (RCP) is that stress becomes oxidative stress.  That oxidative stress prevents the creation of energy and oxidative stress is an indication of inefficient clearing of exhaust.

If magnesium is low, the energy of red blood cells (RBCs) is low and is not able to convert magnesium dependent enzymes properly. This results in a shorter lifespan of RBCs.

On the copper side (ceruloplasmin), oxidative stress increases the need for enzymes, catalase and superoxide dismutase which are what gives the RBCs longer lifespan.

MBR (Magnesium burn rate) is a term that we use to describe the amount of magnesium being lost due to stress. Stress comes in many forms, and may not always be the first things that you think of. One of the main causes of magnesium loss is oxidative stress.

Stages 1 and 2: Mild Magnesium Loss

The 1st Tier of  Oxidative Stress is there is an imbalance between the oxidants (accidents with oxygen) which is producing accidents and oxidative stress. This is also called the initiation stage.

Stage 3: Sustained Magnesium Loss

The 2nd Tier of  Oxidative Stress is an even bigger imbalance between the oxidants and producing oxidative stress which is leading to inflammation (reactive oxygen species – ROS). This is also called the promotion stage.

Stage 4: Chronic Magnesium Loss: Body is Exhausted

The 3rd Tier of  Oxidative Stress is called cytotoxicity which means that cell death is happening on a bigger scale and starting to cause more and more ROS which is then changing our gene expression (DNA). This is also called progression stage.

Hierarchical Oxidative Stress Model

Magnesium Table

1st Tier of Oxidative Stress

Mild Magnesium Loss

2nd Tier of Oxidative Stress

Sustained Magnesium Loss

3rd Tier of Oxidative Stress

Chronic Magnesium Loss

Stage 1 Stage 2 Stage 3 Stage 4
Fatigue Anxiety & panic attacks Arteriosclerosis Alcoholism
Constipation Arthritis Blood clots ALS (Lou Gehrig’s disease)
Dizziness (vertigo) Asthma Bowel disease Alzheimer’s
Dysmenorrhea
(excessive menstrual pain)
Attention Deficit Disorder Calcified mitral valve
(mitral valve prolapse)
Cancer (breast, colon, prostate)
Facial twitches Backache, upper back: excess cortisol CFS/ME
(Chronic Fatigue Syndrome /
Myalgic Encephalomyelitis)
Cardiac afibrillation
Food cravings
(especially sugar, caffeine, simple carbs)
Backache, lower back: emotional Celiac disease Congestive heart failure
Headaches Cystitis Cerebral palsy Eclampsia
Heart palpitations Ear infections Chronic kidney disease Emphysema (COPD)
Hiccups Gluten sensitivity Concussion Myocardial infarction
Hyperglycemia Hyperlipidemia
(high cholesterol, triglycerides)
Depression Obesity
Hypoglycemia Hypertension Diabetes Parkinson’s disease
Irritability Insomnia Epilepsy/seizures Renal failure
Loss of appetite Insulin resistance
(pre-diabetes)
Endothelial dysfunction
(dysfunction of the lining of blood vessels)
SIDS
Mood swings Migraines Failure to thrive Starvation
Muscle cramps, spasms Multiple pregnancies
(exacerbates Magnesium deficiency)
Heart arrhythmias Stroke
Nausea Nerve problems Hormonal imbalance Sudden cardiac death
Nervousness Obesity Hyperparathyroid Ventricular fibrillation
Poor memory / concentration Osteopenia (precursor to osteoporosis) Hypothyroid
Pregnancy
(exacerbates Magnesium deficiency)
PMS Kidney disease
Raynaud’s syndrome Poor concentration Liver disease
Weakness Pre-diabetes; insulin resistance Metabolic Syndrome
Sinusitis Miscarriage
TMJ disorder Mitral valve prolapse
(Calcified mitral valve)
Weight gain
(especially on waist)
Multiple sclerosis
Obesity, severe
Osteoporosis

 

1st Tier of Oxidative Stress

Mild Magnesium Loss

Stage 1 Stage 2
Fatigue Anxiety & panic attacks
Constipation Arthritis
Dizziness (vertigo) Asthma
Dysmenorrhea
(excessive menstrual pain)
Attention Deficit Disorder
Facial twitches Backache, upper back: excess cortisol
Food cravings
(especially sugar, caffeine, simple carbs)
Backache, lower back: emotional
Headaches Cystitis
Heart palpitations Ear infections
Hiccups Gluten sensitivity
Hyperglycemia Hyperlipidemia
(high cholesterol, triglycerides)
Hypoglycemia Hypertension
Irritability Insomnia
Loss of appetite Insulin resistance
(pre-diabetes)
Mood swings Migraines
Muscle cramps, spasms Multiple pregnancies
(exacerbates Magnesium deficiency)
Nausea Nerve problems
Nervousness Obesity
Poor memory / concentration Osteopenia (precursor to osteoporosis)
Pregnancy
(exacerbates Magnesium deficiency)
PMS
Raynaud’s syndrome Poor concentration
Weakness Pre-diabetes; insulin resistance
Sinusitis
TMJ disorder
Weight gain
(especially on waist)

2nd Tier of Oxidative Stress

Sustained Magnesium Loss

3rd Tier of Oxidative Stress

Chronic Magnesium Loss

Stage 3 Stage 4
Arteriosclerosis Alcoholism
Blood clots ALS (Lou Gehrig’s disease)
Bowel disease Alzheimer’s
Calcified mitral valve
(mitral valve prolapse)
Cancer (breast, colon, prostate)
CFS/ME
(Chronic Fatigue Syndrome /
Myalgic Encephalomyelitis)
Cardiac afibrillation
Celiac disease Congestive heart failure
Cerebral palsy Eclampsia
Chronic kidney disease Emphysema (COPD)
Concussion Myocardial infarction
Depression Obesity
Diabetes Parkinson’s disease
Epilepsy/seizures Renal failure
Endothelial dysfunction
(dysfunction of the lining of blood vessels)
SIDS
Failure to thrive Starvation
Heart arrhythmias Stroke
Hormonal imbalance Sudden cardiac death
Hyperparathyroid Ventricular fibrillation
Hypothyroid
Kidney disease
Liver disease
Metabolic Syndrome
Miscarriage
Mitral valve prolapse
(Calcified mitral valve)
Multiple sclerosis
Obesity, severe
Osteoporosis

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