Iron Toxicity Post #33: Lyme has a relationship with Iron dysregulation!

Iron Toxicity Post #33: Lyme has a relationship with Iron dysregulation!

by | May 17, 2016 | General, Iron Toxicity Posts

(Formerly #32

I have always suspected that the Lyme condition had a relationship with iron dysregulation. No definitive proof, just a gut instinct.

A week ago, my fellow practitioner, Shawn Bean informed me that the genetic defect that shows the highest for folks with Lyme is the gene for Hemochromatosis (HFE). HFE is an iron loading disorder that is woven through my previous iron toxicity posts.

I saw this provocative article from HealthNutNews this morning:
www.healthnutnews.com/study-shows-stevia-kills-lyme-disease-pathogen-better-than-antibiotics/

Please read this article slowly to appreciate that Stevia out performs anti-biotics!

Then I found this excellent article from Iron and Omega on stevia’s properties here:
https://d1aettbyeyfilo.cloudfront.net/thercp/30330651_1661864910568Iron_and_stevia.pdf

This paragraph from Ferrazzano’s study should make your eyes pop:

“Studies of Stevioside and their related compounds include the benefits of being anti-helminthic, anti-rheumatic, anti-diarrheal, diuretic, anti-hyperglycaemic, anti-hypertensive, antioxidants, anti-viral, immunomodulatory actions and gastro and renal-protective.” 

Ferrazzano, G.F., et al. (2015). Is Stevia rebaudiana Bertoni a Non Cariogenic Sweetener? A Review.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274104/

Which begs the question, how does Stevia (Steviocide) do all of those things?

Well, it turns out that Stevia has what’s called “Ferric Reductase Properties”. The inability to manage the valence and oxidative properties of iron is very destructive to our cells, tissues, organs and overall health. 

What the study is showing, is that Stevia is facilitating management of these valence of iron and resulting oxidative stress via this ferric reductase action. 

So while the solution may appear to be “use stevia to reduce inflammation and oxidative stress”, how about re-thinking your iron status?

I now believe that it’s absolutely time to re-think the following: 

  1. The concept of disease
  2. What toxic, out-of-control metal is feeding the oxidative stress causing these symptoms, and 
  3. Does the label (disease) even apply anymore?

It puts a different spin on Lyme when we look at it in this light, especially when Lyme is so vogue in the modern era.

A votre sante!

For Facebook Discussion:
https://www.facebook.com/groups/MagnesiumAdvocacy/permalink/1027615630639839/

Iron Toxicity Post #32: How oxidative stress created by iron cause metabolic changes. (Formerly ITP#31)

Iron Toxicity Post #32: How oxidative stress created by iron cause metabolic changes. (Formerly ITP#31)

by | May 17, 2016 | General, Iron Toxicity Posts

(Formerly #31)

Please review this important 14-page PowerPoint to better understand the rusting properties of iron that occur inside our bodies:

Welch, K.D., Aust, S. D. (2005). “Iron Chelates and Unwanted Biological Oxidations.”
https://sfrbm.org/site/assets/documents/frs/AustIronChelates.pdf

Yes, this is complex and even I do not fully understand all these concepts. I am unnerved by what this PPT is saying and implying, particularly as it relates to DNA dings, ascorbic acid and lipid peroxidation…

For those who think they are anemic and do not really know their true iron status. Please get the full Monty Iron Panel and gain critical insight into your iron and ceruloplasmin (Cp) status.

Iron supplements only feed these problems when your understanding of your iron status is backwards and you are not iron anemic, but ceruloplasmin anemic!
There is a major difference between iron deficiency and iron dysregulation. Ferritin only blood test is not at all adequate to assessing true iron metabolism status. 

Look at it this way, when was the last time you used the amount of gas in your car determine your fuel efficiency?

A votre sante!

MORLEY M. ROBBINS

For Facebook Discussion:
https://www.facebook.com/groups/MagnesiumAdvocacy/permalink/1025157620885640/

MAG-pie Alert!… #29 TOXICITY OF IRON

MAG-pie Alert!… #29 TOXICITY OF IRON

by | May 8, 2016 | General, Iron Toxicity Posts

MAG-pie Alert!… #29 TOXICITY OF IRON
Now, let’s pull the curtain ALL the way back:
o          You point out the sugar issue & it’s effect on Calcium & Phosphorous, but where’s Maggie. Yes,
there 18+ minerals involved in Bone Matrix, but as you likely know, the BIG three are Ca, P &
Mg.
o          It’s worth noting that there are three Calcitrophic Hormones, Calcitonin, PTH, & Hormone-D…
ALL 3 are dependent on Mg to work. So that when Ca is rising, it’s worth asking,
“Where’s Maggie?…”
o          You raise the issue of sugars in the blood, & it’s worth noting that Ca stimulates Insulin release,
but Mg CALMS it. In fact, the Ca/Mg ratio is called the “Blood Sugar Ratio”
o          Furthermore, it is Mg that activates the Tyrosine Kinase enzyme to allow Insulin INTO the cell,
& Mg is critical in 6 of the 9 enzymes to breakdown Glucose in the Krebs Cycle.
o          Also, Mg is central to the release & dynamics of Pancreatic enzymes & function…sugar
What’s my point ^^^^?
You aptly raise the “sugar issue,” but deftly sidestep an important question: “Where’s Maggie?” & “WHY is there a “sugar issue?”
It’s worth noting that excess, unbound Iron has a devastating effect on the cells, the tissues & the organs:
o          Iron has a magical effect on chasing Mg out of the cell which affects Pumps, Channels, etc that affect Electrolyte balance….
o          Iron has a magical effect on inviting more Calcium into the cell & bloodstream. It delights in affecting the Mito Calcium Uptake pathway which   dramatically affects Iron, Ca, & Mg status…
o          Iron, in excess, is toxic to Phosphorous… and who knows digestion better than you, and the impact that excess Iron has on Digestive Enzymes, stomach pH, and the natural production of
Phosphorous is notable…
o          Iron is attracted to the Beta cells of the Pancreas & it is well established that “Iron Overload” is the CAUSE of Diabetes… I’ll go out on a limb and state BOTH T1D and T2D, but for
different reasons…
o          Iron Overload & Mg deficiency are clearly implicated in Metabolic Syndrome –      – one begets the other, unfortunately…
o          Iron Overload is recognized as WHY there is “Insulin Resistance,” as it chases Mg from the Tyrosine Kinase enzyme
o          I could go on, but I believe you get the point…
Absolutely, you could throw some PhosFood at the “Sugar Symptom,” but what I’ve devoted MAG to is addressing the CAUSE… I want folks to get to the ROOT of why there is a sugar issue & why there is missing Mg that profoundly affects the balance of Ca<>Mg<>P and many other seesaws in the body…
There clearly is an Iron issue when her Ceruloplasmin (Cp) is hovering at 18-20, & it should be @ 35-40 mg/dL. That low Cp, I believe, is CAUSED by excess Iron in her system & her diet & THAT Elephant in the room that you are walking around needs to be addressed, so that her Magnesium can get normalized, so that her “Blood Sugar Ratio” can get normalized, so that her Ca/P ratio can get normalized.
Does that ^^^^ make sense to you?… I know you’re not a “mineral guy,” but Minerals DO matter. It’s important that in our responses, esp. on MAG, that we address the totality of dynamics as it is TOO EASY to address a symptom & NOT address the root cause… That’s where the REAL payoff is.
So, I’m confident that there are aspects of these dynamics that I’ve overlooked, & please feel free to fill in the gaps. All I ask is that you think more broadly in your responses to get to the ROOT of the matter so that we can ALL solve our metabolic dysfunctions, not merely treat them…
A votre sante!
MORLEY M. ROBBINS

Iron Toxicity Post #31: When iron is out of control, it has profound effect on magnesium status!

Iron Toxicity Post #31: When iron is out of control, it has profound effect on magnesium status!

by | May 7, 2016 | General, Iron Toxicity Posts

(Formerly Mag me with a spoon #1)

Ever wondered what happens when iron and magnesium get together and the effect of iron overload in the liver on magnesium status. 

Some important clues:

  • Cysteine dioxygenase has an iron atom at its core and in the same way that iron gets into the core of hemoglobin, I’m assuming that it’s bioavailable copper that enables that enzyme to work, as well When it doesn’t, then we have sulfate issues.
  • There is an entirely different pathway with sulfite oxidase, which by the way relies on molybdenum, but folks can have issues with sulfates as well there.
  • Rheumatoid arthritis is one of the 30+ autoimmune conditions that have exploded on the scene since the introduction of HFCS and GMO products that coupled with the enrichment of flour with iron filings have created untold stress for our livers.  This has caused a massive loss of liver copper and build-up of liver iron. (You might look into the work of Mary Fields, PhD in the early 1980’s)
  • Rheumatoid arthritis = low bioavailable copper (and by inference, high unbound iron.)
  • When iron is out of control, and in a state of overload, it has a profound effect on both magnesium status and tumor necrosis factor alpha (TNFa):

— Magnesium deficiency is the metabolic precursor to the inflammatory cascades triggered by substance P when intracellular magnesium is too low: 

Weglicki, W.B., Phillips, T.M. (1992). “Pathobiology of magnesium deficiency: a cytokine/neurogenic inflammation hypothesis.”

https://www.ncbi.nlm.nih.gov/pubmed/1384353

— Iron overload in the liver has a devastating effect on liver chemistry and causes a rise in TNFa:

Brown, K.E., et al. (2006). “Chronic iron overload stimulates hepatocyte proliferation and cyclin D1 expression in rodent liver.”

https://pubmed.ncbi.nlm.nih.gov/16890145/

— As you note later in this thread, there is a decided impact of sulfites on thiamine (B1) status and it turns out that thiamine deficiency drives an increase in iron:

Itokawa, Y. (1987). “Tissue minerals of magnesium-deficient rats with thiamine deficiency and excess.”

 https://pubmed.ncbi.nlm.nih.gov/3821175/

Talk about a perfect metabolic storm! There are hundreds if not thousands of articles that tie magnesium deficiency to elevated TNFa and vice-versa. Which is the chicken, which is the egg? It would be an endless debate to some extent.  We are in total agreement re the impact of too little magnesium. 

We just need to pull the curtain back all the way to reveal that magnesium loss is always in response to a stressor. It is how we are wired as a species.  As I study the cellular enzyme pathways, the impact of ROS (reactive oxygen species), the central role of antioxidant enzymes (which is produced in the liver) and the fact that low ceruloplasmin ==> high iron stored in the liver.  Iron stress in the liver is a cellular nightmare and by inference, iron is especially toxic to magnesium status in the liver.

Given that information, I’m more inclined to say that the real threat is our exposure to dietary and supplemental iron, which is further aggravated by the twisted and false belief that folks are iron anemic, it creates a perfect metabolic storm.

In my world, based on my research and what I’ve been able to piece together from hundreds & hundreds of articles over 7 yrs of reading & reflection, the iron enriched wombs of women today are producing children who are iron dysregulated. The agricultural, food and medical systems only further that iron dysregulation. Vaccines only send this dysregulation into stratospheric orbit in a body that has low production of both copper-dependent antioxidant enzymes, as well as low magnesium. 

I am convinced that iron is the 1st offender, and magnesium is taking it on the chin whenever we are under stress.

Hope that makes sense and connects some important mineral dots!

A votre sante!

MORLEY M. ROBBINS

For Facebook discussion:

https://www.facebook.com/groups/MagnesiumAdvocacy/permalink/1027207120680690/

Iron Toxicity Post #30: How blood pressure gets tweaked

Iron Toxicity Post #30: How blood pressure gets tweaked

by | May 5, 2016 | Iron Toxicity Posts

Ever wondered why I obsessed over Mag RBC? 

Resnick, L.M., et al. (1987). “Intracellular pH in human and experimental hypertension.”
http://www.pnas.org/content/84/21/7663.full.pdf

Please read the discussion slowly and carefully as all the clues are there.

There are five important questions to ask:

  1. Why is intracellular pH not a part of regular healthcare checkups?
  2. Why aren’t people made aware that insulin increases cellular pH, especially when the Mg-dependent, tyrosine kinase enzyme allows Insulin into the cell?
  3. Why aren’t we told that increased dietary calcium:
    a) Lowers pH in the cell and
    b) Elevates my blood pressure?
  4. What role might increased iron dysregulation have on magnesium, calcium and pH status inside my cells?
  5. How might this one study call for a complete reversal in the treatment of Calcium, iron, and thyroid related conditions at the expense of magnesium, copper and adrenals?

It is food for serious thought and reflection!

A votre sante!
MORLEY M. ROBBINS

For Facebook Discussion:
https://www.facebook.com/groups/MagnesiumAdvocacy/permalink/1023870307681038/