Magnesium and copper are essential for activating alkaline phosphatase and lysyl oxidase in the bone.

Magnesium and copper are essential for activating alkaline phosphatase and lysyl oxidase in the bone.
All neurodegenerative conditions are clear signs of metabolic dysfunction caused by mineral dysregulation, especially copper, iron and magnesium.
Iron is the ‘stressor’ that is causing excess loss of magnesium. It is the causative agent to create oxygen stress, and nitrogen stress that is at the heart of neutering ceruloplasmin. Ceruloplasmin is the very protein/enzyme that is essential to properly manage this toxic metal and Morley talks about the studies on the structure and function of ceruloplasmin and the relationship with iron.
Arrhythmias and how potassium is affected by excess iron. Rats have the ability to create their own vitamin C and also have the ability to excrete iron.
Morley speaks on an article he found regarding the effects of iron overload on cardiomyocytes (heart) and how important ceruloplasmin is in managing that iron.
“When iron accumulates, chelatable iron replaces magnesium at the corresponding metal-binding site, promoting selective damage to these proteins.”
How 3,571 proteins require magnesium to work and how iron impacts on this during our lifetime.
“All manner of pathogens – fungal, viral, mycotoxin, bacterial must have iron to flourish and grow”
There is abnormal iron metabolism in rats that are magnesium deficient especially if iron is overloaded in tissues and not blood.
A deficiency of Ceruloplasmin (Cp) is one of the earliest manifestations of Copper deficiency.
Read about the linking between iron overload, lack of ceruloplasmin, cancer and the bookends of iron (both low functional iron and iron overload).