…targets of iron-induced protein oxidative damage in frataxin-deficient yeasts are magnesium-binding proteins.” www.ncbi.nlm.nih.gov/m/pubmed/18280258/ “When iron accumulates, chelatable iron replaces magnesium at the corresponding metal-binding site, promoting selective damage to these…
Iron Toxicity Post #76: ‘Hypoferremia’ (Low Serum Iron) occurs in ANY Inflammatory state
…not low for a “lack of iron!” Wessling-Resnick M. (2010). Iron homeostasis and the inflammatory response. Annual review of nutrition, 30, 105-22. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108097/ But what most practitioners have not been trained in…
Iron Toxicity Post #46: The “Reader’s Digest” version of what causes mitochondrial dysfunction
This is the “Readers Digest” version of what causes mitochondrial dysfunction. I am following this up more information about this topic in the next iron toxicity post. => Metabolic Derangement…
Iron Toxicity Post #7: All manner of pathogens – fungal, viral, mycotoxin etc., MUST have iron to flourish and grow!
(Formerly #1) It has taken me much of 2015 to fully process the many stellar studies reviewed on the toxicity of iron: “Health-e-Iron: prevention is the cure” https://therootcauseprotocol.com/wp-content/uploads/2023/06/Healthy-e-iron-Prevention-is-the-Cure.pdf Brace yourself!…
FAQ – Handbook (aka Manual) Common Questions
…and around the topic of pregnancy and breastfeeding: https://therootcauseprotocol.com/webinar-archive/ Read Iron Toxicity Posts about pregnancy here: The “gestation and birth” of iron toxicity And here: If you’re 6-9 months Pregnant,…
Iron Toxicity Post #22: There is a difference between ‘Iron Deficiency and ‘Iron Dysregulation’!
…a huge difference between “Iron deficiency” (very rare) and “Iron dysregulation” (very common). It’s time we all learn this fact about iron and copper metabolism. I would like to ask…
Iron Toxicity Post #2: Things that go ‘bump’ in the night
…http://freetheanimal.com/2015/06/enrichment-theory-everything McCord, J.M. (2004). “Iron, free radicals, and oxidative injury.” McCord, J.M. (1991). “Is Iron Sufficiency a Risk Factor in Ischemic Heart Disease?” https://www.ahajournals.org/doi/pdf/10.1161/01.cir.83.3.1112 Jian, J., et al. (2009). “Iron…
Iron Toxicity Post #11: If the Sun is the ‘center’ of our Universe, I’m coming to regard Ceruloplasmin as the ‘Sun’ of our universe of metabolic activity.
…ideal state for iron. It is not meant to be stored and measuring Iron in its storage state via the ferritin molecule makes no sense at all. It is akin…
Iron Toxicity Post #39: excess unbound iron is very bad! Get properly tested.
(Formerly ITP#39) Please share this “oldie, but goodie” with your favorite practitioner: Williams, D.M., Lee, G.R., Cartwright, G.E. (1976). “Role of Copper in Mitochondrial Iron Metabolism.” https://ashpublications.org/blood/article/48/1/77/160532/Role-of-copper-in-mitochondrial-iron-metabolism I am also…
Iron Toxicity Post #32: How oxidative stress created by iron cause metabolic changes. (Formerly ITP#31)
…full Monty Iron Panel and gain critical insight into your iron and ceruloplasmin (Cp) status. Iron supplements only feed these problems when your understanding of your iron status is backwards…