Iron Toxicity Post #72: Iron deficiency is associated with RESISTANCE to infection
There is no anemia on planet earth, but there is a pandemic of anemia!
Where are we headed today? This will also be known as “anemic advisory action alert #1!”
Folks, I’ve had it. It is appalling how conventional practitioners are about “anemia” vs. “anemia, which involves retinol-A!”
I intend to introduce several key concepts in this post to set the stage for future posts and explorations about the abject unawareness of what’s causing copper<>iron dysregulation. The ubiquitous condition of low functional iron, that is lazily and incorrectly being called anemia or iron deficiency, when it is anything but that! It’s time to set the record straight!
Let me explain further, as you well know that this is not the first time that I have made this assertion.
Anemia, as we will learn going forward, is very much a key and contributing factor for the rampant level of metabolic dysfunction and mineral dysregulation that is gripping the failing life-force of earthlings.
There are numerous factors that allow this anemic condition to exist and be the scourge that it truly is:
You might re-read this second bullet point again slowly to absorb the penetrating importance of adiponectin (APN, produced by the ADIPOQ gene) inside our liver and adipocytes (fat cells) that is noted below in the 1st diagram. That list of clinical conditions is the Who’s Who of chronic conditions that our loved ones and we are all suffering from.
I will be focusing on these and related factors in coming posts and will be sure to provide proper scientific studies and notations to back-up my statements.
I simply wanted to drop some truth bombs to activate your neurons and allow you to assimilate on a deeper and more extensive level, some of the missing factors in this quest for metabolic truth. Especially as it relates to our mineral buddies, magnesium, copper and iron.
Bottom line: We have been grossly misled, and misinformed for the past century!
The series of dietary mistakes is building cumulatively generationally, in large part but not solely due to the following practices:
We have much to discus and discuss, we will.
And in closing, let me encourage each of you to watch the relatively new film by Australian Chef, Pete Evans, entitled The Magic Pill.
I would sincerely and formally request that this thread not devolve into a religious war of Paleos vs. Vegans – that is the farthest thing from my mind.
What I do want to do is highlight the penetrating comment that Rangan Chatterjee, MD, (2001 Graduate of the University of Edinburgh Medical School) and star of BBC One series, Doctor in the House. has to share with his cameo appearance in this film. Despite his brief role, he asks sterling, critical and stunning question of the audience:
“What are you eating?”
It is a topic that warrants further exploration, especially in light of the numerous factors that are enumerated above that are clearly decimating and assassinating our metabolism.
It is high time we take stock of how natural, how unprocessed, and most importantly, how organic is our diet to ensure that we are getting the nutrients and cofactors that are essential to ensure optimal metabolic function.
What do we need in our diet?
What have we been subjected to?
To paraphrase Dr. Chatterjee’s insightful question,
“What in the world are we eating?”
What is becoming increasingly clear to me is how interrelated all of these factors are, and while I’m introducing a new metabolite, adiponectin, you will take comfort in knowing that in the presence of retinol deficiency and a lack of bioavailable copper, this blockbuster hormone simply loses its effectiveness and regulatory zeal. When you take stock of the breadth and depth of this hormone’s dysfunction, it is not hard to see that this element, too, has been yet another, in a series of unintended consequences from this past century of dietary decisions to dictate our health.
So, we have more to explore with these and related issues and in the spirit of the Memorial weekend, I wish you all well, as we start yet another summer season in North American and another winter season down under! May it be a safe and relaxing weekend for all, and I’ll look forward to your comments and questions, as well as our continued exploration of these amazing factors in the coming weeks.
Danke for your time and attention!
A votre sante!
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The Irony of Retinol!
This post will introduce what will become a series of posts focusing on real vitamin-A, as known as retinol, the animal-based form of that key nutrient. (Retinol-A is very different in role and function that beta-carotene)
Real vitamin-A (retinol-A) has been a part of the Root Cause Protocol (RCP) from day 1, in large part because of its known role in the synthesis of the ceruloplasmin protein that expresses as the ferroxidase enzyme. Ferroxidase is the master anti-oxidant enzyme that no one on the Internet talks about, and is akin to “Voldermort” in your Doctor’s office!
Nonetheless, we will continue to march forward and advance the knowledge and understanding of human physiology and start teaching ourselves about the profound regulatory roles of retinol-A.
As an opener, here’s a recent interview that I did this week with Ben Edwards, MD, founder of Veritas Medical Group. Get ready to be surprised, and even amazed, at what retinol-A is involved in.
https://veritasmedical.com/podcast/ (Using the drop-down menus, select 2018 and category “RCP – Morley Robbins”, then select May 02.18 “You’re the Cure, April 30, 2018)
Now, here’s the punch line.
Retinol-A is an absolute requirement for building blood and especially hemoglobin. Yeah, even I was a bit surprised to learn that!
The first recorded study to make the causal link between retinol-A and curing anemia was in 1855! No, that is not a typo! Theophilus Thompson, MD, FRS, a noted physician in London at the time proved that cod liver oil cured folks of anemia, which is a term that technically means: “low red blood counts, low hemoglobin and low hematocrit” Interesting right?
Some 120+ years later, Robert E. Hodges, MD and his colleagues completed a blockbuster study in 1978 on the impact that real vitamin A (retinol-A) deficiency had on the process of making blood (hematopoiesis). Here’s the link to the abstract for Hodges, 1978:
Hodges, R.E., et al. (1978). “Hematopoietic studies in vitamin A deficiency”
academic.oup.com/ajcn/article-abstract/31/5/876/4650239 (It is a key study for those interested in purchasing it)
Attached above is a key graphic from that Hodges, 1978 study. You will be shocked to learn what they discovered that iron had no correlation to restoring hemoglobin levels! Furthermore, that retinol had a 78% correlation with restoring hemoglobin!
Iron, acting alone, will not correct anemia. That has been known since 1855! When hemoglobin goes south, it is more an issue of hemoglobin metabolism not a shortage of the heavy metal, iron.
Let me clarify those two points. There is a belief in society, and clinical circles, that only iron alone can restore levels of hemoglobin. Now we all know that iron plays a key role in holding oxygen in that transport protein so that tissues can use that oxygen for respiration. This post is not challenging that obvious truth.
What this post is challenging is the mind numbing and incorrect misconception that iron is the best answer to blood tests that show iron is low, when for a fact that iron is dysfunctional!
As the Figure above clearly shows, when iron gets added, the hemoglobin does rise for a brief period, and then falls until retinol is added. Any heavy metal, yes, iron is a heavy metal, will cause RBC production to rise, but it is not sustainable, just as this study proves.
I would caution folks to not take statements out of context in this kind of post. Context is king! It is essential that you do the following:
98% of our daily iron requirements come from the iron R.E.cycling System and not our diet. Contrary to the beliefs bantered about on the Internet. We are meant to recycle our iron, not keep eating it!
We have much to learn, and much to discuss in the coming weeks to better understand the true dynamics of copper<>retinol<>iron dynamics. Health and nutrition practitioners that do not understand mineral and vitamin complexes metabolism have misled us. Undaunted, we will spread this good news, far and wide on MAG FB Group, and communities within and outside of FB.
Know that you’ve got your retinol-A bases covered if you’re doing the RCP. But what we will all need to do is unlearn and relearn how blood is really made in the human body. You will find these truths ironic and in conflict with much of your conventional training found on most sites on the Internet,
Stay tuned to be prepared to be further enlightened by this copper<>retinol<>iron dynamics.
A votre sante!
Morley M. Robbins
For Facebook Discussion:
Okay, folks, it’s officially Valentine’s Day back in the States. Who “loves” you? Well, I certainly do!
This post will be short and “sweet,” (calorie-free!), will take 33 min out of your day, but it will change your life forevermore, of that I’m confident. Here’s the link:
In my humble opinion, Thomas E. Levy, MD, JD deserves the Nobel Prize for his compilation of research, his insights and his power-packed delivery on the toxicity of iron, especially as it is ubiquitously found in our grains, cereals, and baked goods! My favorite quotation from his presentation:
“Iron is the primary way in which you increase intracellular oxidative stress, have malignant transformation, and have chronic degenerative disease — everywhere!”
This is a blockbuster set of studies and is required reading of all. I am especially grateful to Valerie Engh for bringing this to our attention recently. I am excited to share these ironic pearls with the entire MAG FB Group.
I should warn you however, that despite his keen understanding of the toxicity of iron, he’s still chasing copper toxicity and iron anemia. Furthermore, he seems to lack a true solution, but we seem to have that covered:
So, this post is my V-day gift to you. All I ask for, in return, is that this forward-thinking, proactive and iron-savvy group send it viral!
Have a blessed Valentine’s Day and do enjoy this treat!
A votre sante!
For Facebook Discussion:
There is 5 times more iron in breast cancer cells than normal cells.
I’m confident that many will not like what this post has to say. Quite frankly, even I was stunned by the compelling cancer research that I stumbled upon (was guided to) earlier this week.
Before you settle into this hard-hitting post, I would like you to witness the combined impact of hydrogen peroxide (H2O2), ascorbic acid and iron sulphate. This brief video was brought to my attention by Ben Edwards, MD, and my gifted clinician, “step-down-transformer,” which had received it from one of his gifted ND practitioner buddies.
Please be sure to be sitting down when you watch it, it makes quite the statement!
I’m confident that those who are regulars on MAG FB Group get it, and that you are totally on-board! The video, however, is a compelling example of the iron dynamics that we are seeking to better understand and bring under better control inside our bodies. Know that this is a reaction that can take place inside our cells.
What may surprise you is that even with all that I’ve shared and written about, that even I have a smidgeon of doubt – from time-to-time — that this iron thing is the sole metabolic issue, and that this RCP thing is the sole anti-dote to that iron-induced chaos. After internalizing the research this week, I have absolutely no doubt! My resolve is now locked in.
During my morning research ritual earlier this week, I happened upon a recently released textbook (2014) entitled:
Preedy, V.R. (2014). “Cancer: Oxidative stress and dietary antioxidants”
Victor Preedy is a distinguished professor of nutritional biochemistry at King’s College in London, England. I’ve read other articles and research by Dr Preedy, but none on cancer. (And as my typical ritual, I called to thank him for this amazing body of knowledge).
The material that I’m sharing in this post is from Chapter 13 entitled Iron, Oxidative stress and Cancer. Within that chapter, Iron Homeostasis & Cancer Development: Mechanistic Views” which is co-authored by two gifted Korean iron researchers: Mi-Kyung Sung, PhD, and Yun-Jung Bae, PhD. Here are the key findings that captured my attention:
“A proteomic analysis of TGF-B1 (Transforming Growth Factor-Beta1)-induced epithelial-mesenchymal transition (EMT) in murine hepatocytes indicates that FHC (Ferritin-Heavy Chain) is one of the significantly altered proteins . FHC possesses a Ferroxidase function to a controllable iron pool, suggesting that available free iron may be an important factor to induce EMT and cancer cell migration [emphasis added].”
It is key to understanding this dynamic to know that TGF-Beta1, which is activated by iron, down-regulates [i.e. turns off] ferritin heavy chain enzyme function. That is a major big deal!
The obvious question: How might this present in the serum measurement of ferritin?
 Zhang, K.H., et al. (2009). “Ferritin Heavy Chain-Mediated Iron Homeostasis and Subsequent Increased Reactive Oxygen Species Production are Essential for Epithelial-Mesenchymal Transition”
 Ionescu, J.G., et al. (2006). “Increased levels of transition metals in breast cancer tissue.”
 Kim, D.H., et al. (2009). “15-Deoxy-Delta12,14-prostaglandin J2 upregulates the expression of Heme Oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: Possible roles of Iron and ROS”
Now, please stop reading this post, and study the attached table 1 below that outlines the amount of iron vs. other metals found in breast tissue – tumor cells vs. normal cells.
Do you honestly think that this iron concentration within cancer cells only occurs in breast tissue? Given that breast cancer is a known form of estrogenic cancer, we can certainly conclude that this iron presence is a safe bet for all estrogenic cancers. It certainly seems to seal the deal for the iron <> estrogen connection that is found in those with low bioavailable copper.
What I will add, however, is that the research on the connection between iron-induced metabolic chaos and cancer is growing daily. Please take command of this ironic and obvious environmental and epigenetic metabolic factor that is at the core of cancer metabolism.
The century old awareness that Scientists & Clinicians have had about the Fenton Reaction (discovered in 1894) between ferrous (Fe2+) iron and H2O2, it is important to begin to understand the profound impact that this hydrogen peroxide oxidant has in our bodies and in our metabolism.
What I want to now point out is the central role that H2O2 plays in three key areas highlighted in the research above and noted with asterisks:
Please know, I am beginning to compile a BROAD and DEEP set of facts re. iron <> inflammation <> H2O2 interaction that has pervasive metabolic dysfunctions, which is enough to bogle the mind.
In addition to the above, it is worth noting that iron-induced H2O2 production was the very agent for lipid peroxidation in our arteries and aorta in the 1950’s and beyond. Which was never revealed while the nation and the world was taken hostage by low fat and cholesterol-free diets that were forced upon us by Ancel Keys, PhD, lo these 60+ years ago.
Cholesterol by itself was never the problem. It was the fact that in the presence of iron and thus H2O2, which increased cholesterol being produced in our iron-laden/copper-deficient livers, gets rusty. It is called coronary arterial plaque, but it is rust, nonetheless!
The one aspect of this cancer information that might be worth considering is that treating cancerous tumors with ascorbic acid, while increasingly favored and worthwhile as it overwhelms the cancer cells with oxidative stress, it hardly seems enough or complete given the obvious need to address the prevalence of iron.
It is clear and compelling that we also want to be engaging in a full-scale chelation of iron with Desferoxamine or related chelating agents when in the throes of seeking to resolve these cancerous conditions. It would seem that there is more than adequate justification for this two-pronged approach to assist practitioners in resolving cancer metabolism within their patients’ bodies.
So, there you have it.
The numbers are in, and the evidence is incontrovertible! Table 1, above, is watershed evidence that there is way more to this cancer dynamic than we were ever told. I think it is high time that we ask better questions and seek better options than we’ve been given in the past. It is also high time that we come to accept the central and causative role that iron plays in metabolic dysfunction and mineral dysregulation.
I’ll leave it at that, and wish you the best as each of you pondered the implications of this research.
A votre santé!
Morley M. Robbins
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